The New Indian Journal of OBGYN. Epub Ahead of Print

Correlation of serum lactate dehydrogenase (LDH) level with feto-maternal outcome in normal pregnancy and preeclamptic disorders

Rupali Modak, Dilip Kumar Biswas, Abu Talha, Amitava Pal

ABSTRACT

Objectives: To compare serum LDH level in normal and preeclamptic mothers in antenatal period and to study the correlation of maternal and perinatal outcome with this biomarker in normal and preeclamptic disorder. Methods: A prospective observational study was conducted in the department of obstetrics and gynaecology, Burdwan Medical College, Burdwan for a period of 18 months. Out of 200 pregnant women, 100 were normal pregnant women (control), 57 were mild preeclamptic and 43 had severe preeclampsia (n=100, study groups). Women with singleton pregnancy and cephalic presentation from 24 weeks onwards were enrolled in the study. Demographic and haematological parameters were recorded including the serum LDH levels of both the groups. The serum LDH level was measured in the second trimester at the time of admission and the mothers were followed-up till delivery to assess the maternal and perinatal outcome. Results: Higher level of LDH was observed in pregnant women with mild preeclampsia (553.54±183.33 IU/L) and severe preeclampsia (820.33±196.62 IU/L) as compared to normal pregnant women (196.18±55.96 IU/L). High LDH level had significant correlation with systolic and diastolic blood pressure (p<0.001). Maternal complications were found to be maximum in women with LDH level >800 IU/L. The perinatal mortality was38% in the study groups and had significant correlation with high serum LDH level of >800 IU/L. Conclusion: High serum LDH level correlates well with the poor maternal and perinatal outcome in normal and preeclamptic mothers, but the severity of the disease of preeclampsia is associated with the increased level of this enzyme.